SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody

• Background:

  Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. 3C- like proteinase (NSP5) cleaves the C-terminus of replicase polyprotein at 11 sites (3,4,5) . It recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. It also able to bind an ADP-ribose-1''-phosphate (ADRP) (5) .

• NCBI Gene ID:

  43740578

• Swiss Prot:

  P0DTC1

• Accession Number:

  YP_009742612.1

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  9151

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Homology:

  Predicted reactivity based on immunogen sequence: SARS-CoV 3CL-PRO (NSP5) protein: (87%)

• Buffer:

  SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is supplied in PBS containing 0.02% sodium azide.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  3CL-PRO

• NCBI Official Name:

  ORF1a polyprotein; ORF1ab polyprotein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Gorbalenya. bioRxiv: 2020.

• Background Reference 02:

  Hui et al. Int J Infect Dis. 2020;91:264-266.

• Background Reference 03:

  Zhang et al. Science. 2020; 0:0-0 (2020)

• Background Reference 04:

  Jin et al. Nature, 0:0-0 (2020)

• Background Reference 05:

  Dai et al. Science 0:0-0 (2020)

• Other Product Names:

  3C-like proteinase, 3CLp, nsp5, Non-structure protein 5, Main protease, Mpro

• Tested Applications:

  ELISA, WB

• Protein ID:

  1826688922

• Physical Properties:

  Liquid