DMPK Antibody

CAT: 0223-13-652Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-13-652Size:100 µL
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Background
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
NCBI Gene ID
1760
Swiss Prot
Q09013
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
A-549
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 75kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
DMPK
NCBI Official Name
DM1 protein kinase
NCBI Organism
Homo sapiens
Other Product Names
DM, DM1, DM1PK, DMK, MDPK, MT-PK, myotonin-protein kinase, DM protein kinase, dystrophia myotonica protein kinase, myotonic dystrophy associated protein kinase, myotonin protein kinase A, thymopoietin homolog
Tested Applications
WB
Physical Properties
Liquid

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