Products for Research Use Only
RegisterLogin

DMP1 Antibody

CAT: 0223-60-228Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-60-228Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
NCBI Gene ID
1758
Swiss Prot
Q13316
Accession Number
Q13316
Host
Rabbit
Reactivity
Human
Immunogen
This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DMP1
NCBI Official Name
Dentin matrix acidic phosphoprotein 1
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)
Background Reference 03
Turan, S., et al. Bone 46 (2) :402-409 (2010)
Background Reference 04
Pereira, R.C., et al. Bone 45 (6) :1161-1168 (2009)
Other Product Names
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
Tested Applications
WB
Protein ID
7673998
Physical Properties
Liquid

Related Products

CatalogName
46-832PDMP1 Peptide
55-542DMP4 Antibody
13-652DMPK Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody

Alternative Products

CatalogName
DF8825-01DMP1 Antibody

Popular Products