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ADORA2B Antibody

CAT: 0223-8111-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8111-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2) . Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5) . Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6) .
NCBI Gene ID
136
Swiss Prot
P29275
Accession Number
NP_000667
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
ADORA2B antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (80%)
Buffer
ADORA2B antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ADORA2B antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.
Symbol
ADORA2B
Positive Control 2
Cat. No. 1411 - Mouse Colon Tissue Lysate
NCBI Official Name
Adenosine A2b receptor
NCBI Organism
Homo sapiens
Background Reference 01
Pierce KD, Furlong TJ, Selbie LA, et al. Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem. Biophys. Res. Commun. 1992; 187:86-93.
Background Reference 02
Thimm D, Schiedel AC, Sherbiny FF, et al. Ligand-specific binding and activation of the human adenosine A (2B) receptor. Biochem. 2013; 52:726-40.
Background Reference 03
Blackburn MR, Vance CO, Morschl E, et al. Adenosine receptors and inflammation. Handb. Exp. Pharmacol. 2009; 215-69.
Background Reference 04
Grenz A, Homann D, Eltzschig HK. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid. Redox Signal. 2011; 15:2221-34.
Other Product Names
Adenosine receptor A2b, ADORA2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4501951
Physical Properties
Liquid

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