Unc93b Antibody

CAT: 0223-4553-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4553-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Unc93b Antibody: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
NCBI Gene ID
81622
Swiss Prot
Q9H1C4
Accession Number
AAH33623
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
Unc93b Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
Unc93b Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Unc93b antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56, 66 kDa
Fragment
IgG
Specificity
Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.
Symbol
UNC93B1
Positive Control 2
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Unc-93 homolog B1 (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Tabeta K, Hoebe K, Janssen EM, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol. 2006; 7:156-64.
Background Reference 02
Liu Y, Dodds P, Emilion G, et al. The human homolog of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. BioMed Central Genetics2002; 3:20.
Background Reference 03
Brinkmann MM, Spooner E, Hoebe K, et al. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 2007; 177:265-75.
Other Product Names
Unc93b Antibody: IIAE1, UNC93, UNC93B, Unc-93B1, Protein unc-93 homolog B1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
116284350
Physical Properties
Liquid

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