UNC84B Antibody

CAT: 0223-56-427Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-427Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM) . The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]) .[supplied by OMIM].
NCBI Gene ID
25777
Swiss Prot
Q9UH99
Accession Number
Q9UH99
Host
Rabbit
Reactivity
Human
Immunogen
This UNC84B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-265 amino acids from the Central region of human UNC84B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
80 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SUN2
NCBI Official Name
SUN domain-containing protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Turgay, Y., et al. EMBO J. 29 (14) :2262-2275 (2010)
Background Reference 02
Haque, F., et al. J. Biol. Chem. 285 (5) :3487-3498 (2010)
Background Reference 03
Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314 (8) :1892-1905 (2008)
Background Reference 04
Cerhan, J.R., et al. Blood 110 (13) :4455-4463 (2007)
Other Product Names
SUN domain-containing protein 2, Protein unc-84 homolog B, Rab5-interacting protein, Rab5IP, Sad1/unc-84 protein-like 2, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B
Tested Applications
WB
Protein ID
29337242
Physical Properties
Liquid

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