UNC84B Antibody

• Background:

  SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM) . The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]) .[supplied by OMIM].

• NCBI Gene ID:

  25777

• Swiss Prot:

  Q9UH99

• Accession Number:

  Q9UH99

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UNC84B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-265 amino acids from the Central region of human UNC84B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  80 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SUN2

• NCBI Official Name:

  SUN domain-containing protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Turgay, Y., et al. EMBO J. 29 (14) :2262-2275 (2010)

• Background Reference 02:

  Haque, F., et al. J. Biol. Chem. 285 (5) :3487-3498 (2010)

• Background Reference 03:

  Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314 (8) :1892-1905 (2008)

• Background Reference 04:

  Cerhan, J.R., et al. Blood 110 (13) :4455-4463 (2007)

• Other Product Names:

  SUN domain-containing protein 2, Protein unc-84 homolog B, Rab5-interacting protein, Rab5IP, Sad1/unc-84 protein-like 2, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B

• Tested Applications:

  WB

• Protein ID:

  29337242

• Physical Properties:

  Liquid