UNC13B Antibody

• Background :

  UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) . It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) .

• NCBI Gene ID :

  10497

• Swiss Prot :

  O14795

• Accession Number :

  O14795

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  181 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  UNC13B

• NCBI Official Name :

  Protein unc-13 homolog B

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Sjoeblom T., et.al., Science 314:268-274 (2006) .

• Background Reference 02 :

  Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162 (2007) .

• Other Product Names :

  Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13

• Tested Applications :

  WB, Flow

• Physical Properties :

  Liquid