UNC13B Antibody

• Background:

  UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) . It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) .

• NCBI Gene ID:

  10497

• Swiss Prot:

  O14795

• Accession Number:

  O14795

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  181 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UNC13B

• NCBI Official Name:

  Protein unc-13 homolog B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sjoeblom T., et.al., Science 314:268-274 (2006) .

• Background Reference 02:

  Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162 (2007) .

• Other Product Names:

  Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid