Anti-Unc93b UNC93B1 Antibody

• Background:

  The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

• Description:

  Boster Bio Anti-Unc93b UNC93B1 Antibody (Catalog # A03864) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  IIAE1, UNC93, UNC93B, Unc-93B1, Protein unc-93 homolog B1

• Gene Name:

  UNC93B1

• UniProt:

  Q9H1C4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.

• Immunogen:

  Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. The immunogen is located within amino acids 80 - 130 of Unc93b.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in plasmocytoid dendritic cells (at protein level) . Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Innate Immunity

• Purification:

  Unc93b Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal.

• Molecular Weight:

  66631 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Unc93b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Unc-93 homolog B1 (C. elegans)

• Subcellular Location:

  Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity) . Colocalizes with LAMP5 in large endosomal intracellular vesicles.

• Protein Name:

  Unc-93 homolog B1 (C. elegans)