GITR Recombinant Protein

• Background:

  Tumor necrosis factor receptor superfamily member 18 (Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

• NCBI Gene ID:

  21936

• Swiss Prot:

  O35714

• Accession Number:

  O35714

• Tag:

  C-Fc-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Immunology

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  42.3 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 18

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, Tnfrsf18, AITR, CD357, GITR-D

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3