GITR Recombinant Protein

CAT: 0223-91-947Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-91-947Size:0.05 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor necrosis factor receptor superfamily member 18 (Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
CAS Number
9000-83-3
NCBI Gene ID
21936
Swiss Prot
O35714
Accession Number
O35714
Tag
C-Fc-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
42.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 18
NCBI Organism
Mus musculus
Other Product Names
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, Tnfrsf18, AITR, CD357, GITR-D
Species
Mouse
Physical Properties
Lyophilized

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