GITR Antibody [DTA-1], Rabbit IgG

• Other Statements:

  This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

• NCBI Gene ID:

  21936

• Swiss Prot:

  O35714

• Reactivity:

  Mouse

• Immunogen:

  This antibody was raised by immunising Wistar rats with the CD25+CD4+ T cell line. Hybridoma cells were generated by fusing spleen cells from the immunized rat with P3X63Ag8.653 myeloma cells, assessed for secreting antibodies capable of neutralizing in vitro CD25+CD4+ T cell-mediated suppression of anti-CD3-stimulated T cell proliferation9, and then cloned. This DTA-1 clone secreted a monoclonal rat immunoglobulin G2a (IgG2a) that showed high neutralizing activity.

• Clonality:

  Recombinant Monoclonal

• Clone:

  DTA-1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Cancer

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% Proclin 300.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

• Fragment:

  IgG lambda

• Symbol:

  Tnfrsf18

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 18

• NCBI Organism:

  Mus musculus

• Other Product Names:

  CD357, AITR, GITR-D, Glucocorticoid-induced TNFR-related protein, TNFRSF18, Tumor necrosis factor receptor superfamily member 18

• Tested Applications:

  Flow, WB, IP, Agonism

• Species:

  Rabbit