PAK4 Antibody

CAT: 0223-3077-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3077-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAK4 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
NCBI Gene ID
10298
Swiss Prot
O96013
Accession Number
NP_005875
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience, Cancer
Purification
PAK4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1221 - SW480 Cell Lysate
Concentration
1 mg/mL
Buffer
PAK4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PAK4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
PAK4 antibody is predicted to not cross-react with other PAK family proteins.
Symbol
PAK4
Positive Control 2
Cat. No. 1320 - Human Colon Tissue Lysate
NCBI Official Name
P21 protein (Cdc42/Rac) -activated kinase 4
NCBI Organism
Homo sapiens
Background Reference 01
Jaffer ZM and Chernoff J. p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 2002; 34:713-7.
Background Reference 02
Abo A, Qu J, Cammarano MS, et al. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J. 1998; 17:6527-40.
Background Reference 03
Cotteret S, Jaffer ZM, Beeser A, et al. p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylated BAD. Mol. Cell. Biol. 2003; 23:5526-39.
Other Product Names
PAK4 Antibody: KIAA1142, p21-activated kinase 4, PAK-4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
5031975
Physical Properties
Liquid

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