PAK3 Antibody

CAT: 0223-63-292Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-292Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30) . The protein structure contains 1 CRIB domain.
NCBI Gene ID
5063
Swiss Prot
O75914
Accession Number
O75914
Host
Rabbit
Reactivity
Human
Immunogen
This PAK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human PAK3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Symbol
PAK3
NCBI Official Name
Serine/threonine-protein kinase PAK 3
NCBI Organism
Homo sapiens
Background Reference 01
Kitano, T., et al., Mol. Biol. Evol. 20 (8) :1281-1289 (2003) .
Background Reference 02
Allen, K.M., et al., Nat. Genet. 20 (1) :25-30 (1998) .
Other Product Names
Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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