PAK3 Antibody

• Background:

  PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30) . The protein structure contains 1 CRIB domain.

• NCBI Gene ID:

  5063

• Swiss Prot:

  O75914

• Accession Number:

  O75914

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PAK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human PAK3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PAK3

• NCBI Official Name:

  Serine/threonine-protein kinase PAK 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kitano, T., et al., Mol. Biol. Evol. 20 (8) :1281-1289 (2003) .

• Background Reference 02:

  Allen, K.M., et al., Nat. Genet. 20 (1) :25-30 (1998) .

• Other Product Names:

  Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid