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PAK6 Antibody

CAT: 0223-3073-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3073-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAK6 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
NCBI Gene ID
56924
Swiss Prot
Q9NQU5
Accession Number
NP_064553
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
PAK6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Buffer
PAK6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PAK6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
PAK6 antibody is predicted to not cross-react with other PAK family proteins.
Symbol
PAK6
Positive Control 2
Cat. No. 17-007 - Raji Cell Slide
NCBI Official Name
P21 protein (Cdc42/Rac) -activated kinase 6
NCBI Organism
Homo sapiens
Background Reference 01
Jaffer ZM and Chernoff J. p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 2002; 34:713-7.
Background Reference 02
Yang F, Li X, Sharma M, et al. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 2001; 276:15345-53.
Background Reference 03
Kaur R, Liu X, Gjoerup O, et al. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. J. Biol. Chem. 2005; 280:3323-30.
Other Product Names
PAK6 Antibody: PAK5, PAK5, PAK-5, PAK-6
Tested Applications
ELISA, WB, ICC, IF
Protein ID
9910476
Physical Properties
Liquid

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