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SHP2-IN-33

CAT: 0804-HY-168715Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168715Size:1 Each
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Description
SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC50 of 1.2 μM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC50 of 38 μM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis (Apoptosis), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2[1].
CAS Number
2894017-46-8
UNSPSC
12352101
Target
Apoptosis; MAPKAPK2 (MK2) ; SHP2
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-33.html
Smiles
ClC1=CC=CC(SC2=C(N)N=C(N(C3CCNCC3)C)C=N2)=C1Cl
Molecular Formula
C16H19Cl2N5S
Molecular Weight
384.33
References & Citations
[1]Zhu C, et al. Optimization of SHP2 allosteric inhibitors with novel tail heterocycles and their potential as antitumor therapeutics. Eur J Med Chem. 2025 Jan 15;282:117078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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