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SHP2-IN-33

CAT: 0013-GTR19241041-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241041-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-33 (D13) is a potent allosteric SHP2 inhibitor with an enzymatic IC50 of 1.2 μM. It demonstrates anti-proliferative activity in vitro by inducing cell cycle arrest and apoptosis in Huh7 cells (IC50 = 38 μM) and shows significant in vivo efficacy in a Huh7 xenograft model with good oral bioavailability.
CAS Number
2894017-46-8
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
ClC1=CC=CC (SC2=NC=C (N=C2N) N (C) C3CCNCC3) =C1Cl
Molecular Formula
C16H19Cl2N5S
Molecular Weight
384.33
Storage Conditions
-20°C
Notes
For research use only.

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