Products for Research Use Only
RegisterLogin

HOIPIN-8

CAT: 0804-HY-122882-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-122882-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC[1].
CAS Number
2519537-70-1
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hoipin-8.html
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(F)C=C(C4=CNN=C4)C=C3F)=O
Molecular Formula
C23H15F2N4NaO3
Molecular Weight
456.38
References & Citations
[1]Ken Katsuya, et al. Small-molecule Inhibitors of Linear Ubiquitin Chain Assembly Complex (LUBAC), HOIPINs, Suppress NF-κB Signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Hoipin-8
CAS Number2519537-70-1
PubChem CID146018039
IUPAC Namesodium 2-[(E)-3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoate
Molecular FormulaC23H15F2N4NaO3
Molecular Weight456.4
Topological Polar Surface Area104
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity718
SMILES
CN1C=C(C=N1)C2=CC(=C(C=C2)C(=O)[O-])/C=C/C(=O)C3=C(C=C(C=C3F)C4=CNN=C4)F.[Na+]
InChI
InChI=1S/C23H16F2N4O3.Na/c1-29-12-17(11-28-29)13-2-4-18(23(31)32)14(6-13)3-5-21(30)22-19(24)7-15(8-20(22)25)16-9-26-27-10-16;/h2-12H,1H3,(H,26,27)(H,31,32);/q;+1/p-1/b5-3+;
InChIKey
DLJPWYFLGYVMKV-WGCWOXMQSA-M
Chemical Structure
2D Structure
2D structure of Hoipin-8
CAS: 2519537-70-1
CID: 146018039
Formula: C23H15F2N4NaO3
MW: 456.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass456.10099096
Monoisotopic Mass456.10099096
Topological Polar Surface Area104 Ų
Heavy Atom Count33
Formal Charge0
Complexity718
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-122881-01HOIPIN-1
HY-122881A-01(E/Z) -HOIPIN-1
HY-160589Nav1.8-IN-8
HY-161737-01YT-8-8
HY-N8842-018,8''-Bibaicalein
HY-N136418,8''-Biskoenigine
HY-W032015S21-Bromooctane-8,8,8-d3
HY-D0062-01(-) -8,8-Dichlorocampherylsulfonyl-oxaziridine
HY-153543-01TLR7/8 agonist 8
HY-149583Aβ-IN-8

Alternative Products

CatalogName
E1798-100mgHOIPIN-8
T62826-01HOIPIN-8 sodium
T60703-01HOIPIN-1
KPC80091-01HOIPIN 11a

Popular Products