TP-064

CAT: 0804-HY-114965-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114965-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TP-064, a chemical probe, is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 IC50 of 340 nM) and MED12 (IC50 of 43 nM) . TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM) . TP-064 has anticancer activities[1].
CAS Number
[2080306-20-1]
Product Name Alternative
1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tp-064.html
Purity
99.61
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 50 mg/mL
Smiles
O=C(C1=CC=CC(OC2=CC=CC=C2)=C1)N(CC3=CC(C4CCN(CC4)CCNC)=NC=C3)C
Molecular Formula
C28H34N4O2
Molecular Weight
458.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Kazuhide Nakayama, et al. TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget. 2018 Apr 6;9 (26) :18480-18493.|[2]Yiheng Zhang, et al. PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim Biophys Acta Mol Basis Dis. 2021 Jul 24;1867 (11) :166212.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT4; PRMT6

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