TP-064

• Description :

  TP-064, a chemical probe, is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 IC50 of 340 nM) and MED12 (IC50 of 43 nM) . TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM) . TP-064 has anticancer activities[1].

• Product Name Alternative :

  1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tp-064.html

• Purity :

  99.61

• Solubility :

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 50 mg/mL

• Smiles :

  O=C(C1=CC=CC(OC2=CC=CC=C2)=C1)N(CC3=CC(C4CCN(CC4)CCNC)=NC=C3)C

• Molecular Formula :

  C28H34N4O2

• Molecular Weight :

  458.60

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kazuhide Nakayama, et al. TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget. 2018 Apr 6;9 (26) :18480-18493.|[2]Yiheng Zhang, et al. PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim Biophys Acta Mol Basis Dis. 2021 Jul 24;1867 (11) :166212.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PRMT4; PRMT6

• CAS Number :

  [2080306-20-1]