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Cbl-b-IN-27

CAT: 0804-HY-169005Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169005Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation[1].
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-27.html
Smiles
O=C1NCC[C@@](C2CC2)(C3=CC(N4N=C5N(C4=O)C=C(C=C5C(F)(F)F)CN6CCC[C@@H](C6)C)=CC=C3)O1
Molecular Formula
C27H30F3N5O3
Molecular Weight
529.55
References & Citations
[1]Quinn TR, et al. Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design. J Med Chem. 2024 Aug 22;67 (16) :14210-14233.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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