Biotin-PEG6-Thalidomide

• Description :

  Biotin-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/biotin-peg6-thalidomide.html

• Purity :

  98.32

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCOCCOCCOCCOCCOCCOCCN1C(C(N(C(C2=C3C=CC=C2)=O)C3=O)CCC1=O)=O)CCCC[C@H]4SC[C@@]([C@@]4([H])N5)([H])NC5=O

• Molecular Formula :

  C37H53N5O12S

• Molecular Weight :

  791.91

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [2144775-48-2]