AF-DX 384

CAT: 0804-HY-107652-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107652-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively) [1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
CAS Number
[118290-26-9]
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/af-dx-384.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC=CN=C2N(C3=C1C=CC=C3)C(NCCN4CCCCC4CN(CCC)CCC)=O
Molecular Formula
C27H38N6O2
Molecular Weight
478.63
References & Citations
[1]Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256 (2) :727-33.|[2]Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79 (3) :837-46.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR2; mAChR4

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