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USH2A rabbit pAb

CAT: 0855-ES12410-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12410-01Size:50 µL
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Background
This gene encodes a protein that contains laminin EGF motifs, a pentaxin domain, and many fibronectin type III motifs. The protein is found in the basement membrane, and may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIa and retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Description
This gene encodes a protein that contains laminin EGF motifs, a pentaxin domain, and many fibronectin type III motifs. The protein is found in the basement membrane, and may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIa and retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
UniProt
O75445
Swiss Prot
O75445
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human USH2A AA range: 3731-3781
Target
USH2A
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell projection, stereocilium membrane ; Single-pass type I membrane protein . Component of the interstereocilia ankle links in the inner ear sensory cells. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. .; [Isoform 2]: Secreted.
Gene ID (Human)
7399

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