PD-L1-IN-3

PD-L1-IN-3

• CAS Number: 2953044-29-4
• UNSPSC Description: PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-l1-in-3.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: FC1=CC=C(C2=CSC(OCC3=CC=C(CN)C=C3)=C2C#N)C=C1.Cl
• Molecular Weight: 374.86
• References & Citations: [1]Ważyńska MA, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023 Jul 27;66(14):9577-9591.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported