VHL Ligand intermediate-1

CAT: 0804-HY-49514Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-49514Size:1 Each
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Description
VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs[1].
CAS Number
[2380273-21-0]
UNSPSC
12352005
Target
Ligands for E3 Ligase; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-ligand-intermediate-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=CC=C(C2=C(N=CS2)C)C=C1)NC([C@H]3N(C[C@H](C3)O)C(OC(C)(C)C)=O)=O
Molecular Formula
C22H29N3O4S
Molecular Weight
431.55
References & Citations
[1]Aurigene Discovery Technologies Limited, et al. Preparation of pyridazine derivatives as SMARCA2/4 degraders. World Intellectual Property Organization, WO2019207538 A1 2019-10-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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