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SOS1 Ligand intermediate-3

CAT: 0804-HY-161452Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161452Size:1 Each
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Description
SOS1 Ligand intermediate-3 (Compound 5) is an SOS1 binder that can be used together with pomalidomide for the synthesis of SOS1 PROTACs[1].
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-ligand-intermediate-3.html
Solubility
10 mM in DMSO
Smiles
NC1=CC([C@@H](C)CC2=NC(C)=NC3=C2C=C(O[C@@H]4CNCC4)C(OC)=C3)=CC(C(F)(F)F)=C1
Molecular Formula
C24H27F3N4O2
Molecular Weight
460.49
References & Citations
[1]Li H, et al. Discovery of LHF418 as a new potent SOS1 PROTAC degrader. Bioorg Med Chem. 2024 Apr 1;103:117661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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