VHL Ligand intermediate-2

• Description:

  VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Ligands for E3 Ligase; SOS1

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sos1-ligand-intermediate-2.html

• Purity:

  99.33

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O

• Molecular Formula:

  C28H40N4O5S

• Molecular Weight:

  544.71

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Aurigene Discovery Technologies Limited, et al. Preparation of pyridazine derivatives as SMARCA2/4 degraders. World Intellectual Property Organization, WO2019207538 A1 2019-10-31.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Von Hippel-Lindau (VHL)

• CAS Number:

  2380273-24-3