VHL Ligand intermediate-2

CAT: 0804-HY-49515Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-49515Size:1 Each
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Description
VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs[1].
CAS Number
[2380273-24-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Ligands for E3 Ligase; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-ligand-intermediate-2.html
Purity
99.33
Solubility
10 mM in DMSO
Smiles
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
Molecular Formula
C28H40N4O5S
Molecular Weight
544.71
Precautions
H302, H315, H319
References & Citations
[1]Aurigene Discovery Technologies Limited, et al. Preparation of pyridazine derivatives as SMARCA2/4 degraders. World Intellectual Property Organization, WO2019207538 A1 2019-10-31.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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