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AZD-5672

CAT: 0804-HY-119101-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119101-01Size:1 mg
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Description
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM) . AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM) . AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM) . AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].
CAS Number
780750-65-4
Product Name Alternative
AHPN
UNSPSC
12352005
Target
CCR; P-glycoprotein; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azd-5672.html
Purity
95.74
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C1CCN(CC[C@@H](C2=CC(F)=CC(F)=C2)C3=CC=C(S(=O)(C)=O)C=C3)CC1)CC)CC4=CC=C(S(=O)(C)=O)C=C4
Molecular Formula
C32H38F2N2O5S2
Molecular Weight
632.78
References & Citations
[1]Cumming JG, et al. Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2012 Feb 15;22 (4) :1655-9.|[2]Elsby R, et al. The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug Metab Dispos. 2011 Feb;39 (2) :275-82.|[3]Gerlag DM, et al. Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis Rheum. 2010 Nov;62 (11) :3154-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR5

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