AZD-8835

CAT: 0804-HY-12869-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12869-01Size:5 mg
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Description
AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively.
CAS Number
[1620576-64-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD-8835.html
Purity
98.62
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
Molecular Formula
C22H31N9O3
Molecular Weight
469.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Barlaam B, Discovery of 1- (4- (5- (5-amino-6- (5-tert-butyl-1,3,4-oxadiazol-2-yl) pyrazin-2-yl) -1-ethyl-1,2,4-triazol-3-yl) piperidin-1-yl) -3-hydroxypropan-1-one (AZD8835) : A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers. Bioorg Med Chem Lett. 2015 Nov 15;25 (22) :5155-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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