Products for Research Use Only
RegisterLogin

AZD 9272

CAT: 0804-HY-110254-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110254-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD 9272 is a selective, orally active and brain penetrant mGluR5 antagonist with IC50s of 2.6 nM and 7.6 nM for rat and human receptors, respectively. AZD 9272 shows >3900-fold selectivity over other mGlu receptors[1]2].
CAS Number
327056-26-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AZD_9272.html
Purity
99.87
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC(F)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1
Molecular Formula
C14H6F2N4O
Molecular Weight
284.22
References & Citations
[1]Swedberg MD, et al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J Pharmacol Exp Ther. 2014 Aug;350 (2) :212-22.|[2]Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22 (22) :6974-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MGluR5

Related Products

CatalogName
HY-18053-01AZD 4017
HY-10012-01AZD-5438
HY-15545-01AZD-4818
HY-123791AZD-9819
HY-117714AZD-3161
HY-111245-01AZD-1305
HY-107023AZD 9684
HY-111087AZD-7295
HY-110255-01AZD 2066
HY-19871AZD-3199

Alternative Products

CatalogName
TRC-A808175-100MGAZD 9272
A19738-5AZD 9272 5mg
523125AZD-9272
A19738-25AZD 9272 25mg
A19738-1AZD 9272 1mg
A19738-100AZD 9272 100mg
A19738-50AZD 9272 50mg
A19738-10AZD 9272 10mg

Popular Products