BI-4916

• Description :

  BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study[1][2][3].

• UNSPSC :

  12352005

• Target :

  Phosphoglycerate Dehydrogenase (PHGDH)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bi-4916.html

• Purity :

  98.67

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(OCC)CS(=O)(C1=CC=C([C@H](NC(C(N2C)=CC3=C2C=C(C)C(Cl)=C3Cl)=O)CO)C=C1)=O

• Molecular Formula :

  C23H24Cl2N2O6S

• Molecular Weight :

  527.42

• References & Citations :

  [1]Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31.|[2]Kiweler N, et al. Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis. Nat Commun. 2022 May 16;13 (1) :2699.|[3]Becker B, et al. Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut. iScience. 2024 Feb 8;27 (3) :109173.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2244451-48-5]