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ABT-107

CAT: 0804-HY-108038-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108038-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions[1][2].
CAS Number
855291-54-2
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-107.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[C@H]1(C2CCN(CC2)C1)OC3=CC=C(C4=CC=C(NC=C5)C5=C4)N=N3
Molecular Formula
C19H20N4O
Molecular Weight
320.39
References & Citations
[1]R Scott Bitner, et al. In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease. J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :875-86.|[2]Tanuja Bordia, et al. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Exp Neurol. 2015 Jan;263:277-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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