AGH-107

• Description :

  AGH-107 is a high selective and brain-penetrant agonist of 5-HT7 receptor, with a Ki of 6 nM and EC50 of 19 nM. AGH-107 exhibits high selectivity over related CNS targets, high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/agh-107.html

• Smiles :

  IC1=CC=C2NC=C(C3=CN=CN3CC)C2=C1

• Molecular Formula :

  C13H12IN3

• Molecular Weight :

  337.16

• References & Citations :

  [1]Hogendorf AS, et, al. Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol. Sci Rep. 2017 May 4;7 (1) :1444.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT7 Receptor

• CAS Number :

  [2172907-10-5]