MK-7246

MK-7246

• CAS Number: 1218918-62-7
• UNSPSC Description: MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
• Target Antigen: Prostaglandin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/MK-7246.html
• Solubility: DMSO : 300 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(O)CC1=C(CC[C@@H](N(S(=O)(C2=CC=C(F)C=C2)=O)C)C3)N3C4=C1C=CC=C4
• Molecular Weight: 416.47
• References & Citations: [1]Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist. Mol Pharmacol. 2011 Jan;79(1):69-76.|[2]Gil MA, et al. Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation. Eur J Pharmacol. 2014 Nov 15;743:106-16.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 1