BMSpep-57

CAT: 0804-HY-P3143-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P3143-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1].
CAS Number
[1629655-80-6]
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmspep-57.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2)=O)CO)=O)CC3=CNC4=CC=CC=C34)=O)CO)=O)CC(C)C)=O)CC5=CN=CN5)=O)=O)CC(N)=O)=O)C)C)=O)CC6=CC=CC=C6)=O)C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CCCC)C)=O)CCCC)C)[C@@H]2CC7=CNC8=CC=CC=C78
Molecular Formula
C89H126N24O19S
Molecular Weight
1868.17
References & Citations
[1]Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9 (1) :12392.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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