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NI-57

CAT: 0026-B2854-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2854-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NI-57 is an inhibitor of the bromodomains of BRPF proteins. The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment and activation of MOZ/MORF histone acetyltransferases to chromatin. NI-57 binds to BRPF1B, BRPF2 and BRPF3 with Kd values of 31 nM, 108 nM and 408 nM respectively. It inhibits BRPF1 with an IC₅₀ of 114 nM. It shows functional activity in cellular assays by modulating the phenotype at low micromolar concentrations in cancer and inflammatory models.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36months

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