NLRP3-IN-57

NLRP3-IN-57

• UNSPSC Description: NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing IL-1β levels in LPS plus Nigericin-induced THP-1 macrophages.[1].
• Target Antigen: NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-57.html
• Smiles: COC(C)(/C=C/C/C(C)=C/C[C@@H]1C[C@]2(C(C(C(C3=CC(O)=C(C=C3)O)=O)=C([C@](C2=O)([C@]1(CC/C=C(C)/C)C)C/C=C(C)\C)O)=O)C/C=C(C)\C)C
• Molecular Weight: 700.94
• References & Citations: [1]Hu XY, et al. Anti-inflammatory bicyclic polyprenylated acylphloroglucinols with diverse architectures including an unprecedented 6/6/6 tricyclic core from Garcinia yunnanensis. Bioorg Chem. 2024 Dec;153:107864.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported