α-Glucosidase-IN-57

α-Glucosidase-IN-57

• UNSPSC Description: α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research[1].
• Target Antigen: Glycosidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/α-glucosidase-in-57.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CSC1=NC2=CC=CC=C2C=C1C3=NC(C4=CC=CC=C4)=C(N3)C5=CC=CC=C5)NC6=CC=C(F)C=C6
• Molecular Weight: 530.61
• References & Citations: [1]Khalili Ghomi M, et al. Evaluation of novel 2-(quinoline-2-ylthio)acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo studies on their anti-diabetic properties. Eur J Med Chem. 2024 Apr 5;269:116332.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported