CDK8-IN-4

• Description:

  CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.

• UNSPSC:

  12352005

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_R_-2-__5-_1H-indazol-5-yl_pyridin-3-yl_amino_-2-phenylethanol.html

• Purity:

  99.39

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC[C@@H](C1=CC=CC=C1)NC2=CC(C3=CC4=C(NN=C4)C=C3)=CN=C2

• Molecular Formula:

  C20H18N4O

• Molecular Weight:

  330.38

• References & Citations:

  [1]Cheng Z, et al. Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer. WO2014090692A1

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1613638-82-6