UPF-1069

• Background :

  A selective PARP-2 inhibitor (IC50=0.3 µM and ~ 27-fold selective against PARP-1) .1,2 Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3 Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4

• Conjugation :

  Unconjugated

• Buffer :

  Off-white solid

• Storage Conditions :

  -20°C