Products for Research Use Only
RegisterLogin

Mouse anti Human Rin

CAT: 0579-X1187MSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0579-X1187MSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and Human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
CAS Number
9007-83-4
UniProt
Q13671
Host
Mouse
Species Reactivity
Human, Mouse
Isotype
IgG2b
Clone
27G2
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
WB
Field of Research
Signal Transduction
Assay Principle
Antibody detects recombinant Rin protein expressed in 293 cells by Western blot analysis at a concentration of 0.5 to 1 µg/mL. Does not cross-react with Rit protein. Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as sterile filtered solution containing 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol at pH 7,5 and 3 mM sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Rusyn, E.V., et al. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene 2000, 19, 4685-4694. 2. Lee, C.H. et al. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J. Neurosci. 1996, 16, 6784-6794. 3. Shao, H., et al. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch. Biochem. Biophys. 1999, 371, 207-219.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

Related Products

CatalogName
X1188PRabbit anti Human Rin
N100MMouse anti Human p107
X1237MMouse anti Human IgG
X1185MMouse anti Human Rit
X1603MMouse anti Human Muc1
1031Mouse anti Human CD103
X2781MMouse anti Human CD57
X1841MMouse anti Human Fetoprotein
0541Mouse anti Human CD54
A100MMouse anti Human bax

Alternative Products

CatalogName
GTR19306744Mouse Anti-human IgA
40R-1015Mouse anti Human IgG3
10R-I129AMouse anti Human IgG4
10R-I128AMouse anti Human IgG2
10R-I127AMouse anti Human IgG1
10-I20AMouse anti Human IgM
10C-CR6046M4Mouse anti Human IgE
31-3400-0.1Mouse Anti-Human CD11b
31-3326-0.1Mouse Anti-Human CD61
31-3314-0.1Mouse Anti-Human CD49d

Popular Products