SPP-DM1

• Description:

  SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].

• UNSPSC:

  12352203

• Target:

  Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/spp-dm1.html

• Purity:

  96.29

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@]12[C@H] ([C@@H] ([C@] (O3) ([H]) C[C@] ([C@] (/C=C/C=C (C) /CC4=CC (N (C) C (C[C@]2 ([H]) OC ([C@H] (C) N (C) C (CCSSC (C) CCC (ON5C (CCC5=O) =O) =O) =O) =O) =O) =C (C (OC) =C4) Cl) ([H]) OC) (NC3=O) O) C) O1

• Molecular Formula:

  C44H59ClN4O14S2

• Molecular Weight:

  967.54

• References & Citations:

  [1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Maytansinoids

• CAS Number:

  452072-20-7