SPP-DM1

• Description :

  SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].

• UNSPSC :

  12352203

• Target :

  Drug-Linker Conjugates for ADC

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/spp-dm1.html

• Purity :

  96.29

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSSC(C)CCC(ON5C(CCC5=O)=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

• Molecular Formula :

  C44H59ClN4O14S2

• Molecular Weight :

  967.54

• References & Citations :

  [1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Maytansinoids

• CAS Number :

  [452072-20-7]