SPP

• Description:

  SPP (N-succinimidyl 4- (2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].

• Product Name Alternative:

  N-succinimidyl 4- (2-pyridyldithio) pentanoate

• UNSPSC:

  12352203

• Hazard Statement:

  H315, H319, H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/spp.html

• Purity:

  96.01

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (SSC1=NC=CC=C1) CCC (ON2C (CCC2=O) =O) =O

• Molecular Formula:

  C14H16N2O4S2

• Molecular Weight:

  340.43

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12 (6) :1762-73.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number:

  341498-08-6