SPP

• Description :

  SPP (N-succinimidyl 4- (2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].

• Product Name Alternative :

  N-succinimidyl 4- (2-pyridyldithio) pentanoate

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/spp.html

• Purity :

  96.01

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(SSC1=NC=CC=C1)CCC(ON2C(CCC2=O)=O)=O

• Molecular Formula :

  C14H16N2O4S2

• Molecular Weight :

  340.43

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12 (6) :1762-73.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number :

  [341498-08-6]