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AMCC-DM1

CAT: 0804-HY-128951-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-128951-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMCC-DM1 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker AMCC to make antibody drug conjugate. AMCC is a noncleavable linker[1].
CAS Number
1228105-53-0
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smcc-linker.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSC(C5)C(N(CC6CCC(C(O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
Molecular Formula
C47H63ClN4O14S
Molecular Weight
975.54
References & Citations
[1]Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28 (5) :1371-1381.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids

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