EPI-X4

• Target:

  CXCR

• Related Pathways:

  Immunology/Inflammation|||Autophagy|||GPCR/G Protein

• Bioactivity:

  EPI-X4 (hSA408–423 peptide), with an IC50 of 8.6 ?M, serves as an antagonist for the C-X-C motif chemokine receptor 4 (CXCR4) . It inhibits CXCL12-mediated signaling and reduces chemokine-driven migration and invasion of leukemia cells. Furthermore, it demonstrates anti-inflammatory effects in a mouse model and possesses antiviral properties against CXCR4-tropic HIV, maintaining the same IC50.

• Smiles:

  C ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC1=CC=C (O) C=C1) NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC (C) C) N) =O) [C@H] (C) C) =O) CCCNC (=N) N) =O) =O) [C@@H] (C) O) =O) CCCCN) =O) CCCCN) =O) [C@@H] (C) C) (=O) N2[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (=O) N3[C@H] (C (N[C@H] (C (N[C@@H] (CC (C) C) C (O) =O) =O) [C@@H] (C) O) =O) CCC3) [C@@H] (C) O) =O) CO) =O) [C@H] (C) C) =O) CCC (N) =O) =O) CCC2

• Molecular Formula:

  C84H144N22O23

• Molecular Weight:

  1830.18

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  930280-31-2