EPI-X4

CAT: 0931-TP2690-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TP2690-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
930280-31-2
Target
CXCR
Related Pathways
Immunology/Inflammation|||Autophagy|||GPCR/G Protein
Bioactivity
EPI-X4 (hSA408–423 peptide), with an IC50 of 8.6 ?M, serves as an antagonist for the C-X-C motif chemokine receptor 4 (CXCR4) . It inhibits CXCL12-mediated signaling and reduces chemokine-driven migration and invasion of leukemia cells. Furthermore, it demonstrates anti-inflammatory effects in a mouse model and possesses antiviral properties against CXCR4-tropic HIV, maintaining the same IC50.
Smiles
C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCCCN)=O)[C@@H](C)C)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@@H](C)O)=O)CCC3)[C@@H](C)O)=O)CO)=O)[C@H](C)C)=O)CCC(N)=O)=O)CCC2
Molecular Formula
C84H144N22O23
Molecular Weight
1830.18
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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