EPI-X4 TFA

• Bioactivity :

  EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4) . It effectively prevents calcium mobilization and receptor internalization triggered by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells with CXCR4 expression, at concentrations between 0.8 and 1,000 µM. Moreover, EPI-X4 hampers the CXCL12-driven migration of both Jurkat T cells and human CD34+ hematopoietic stem cells. In an acute allergic airway hypereosinophilia mouse model, EPI-X4 intrinsically decreases Cxcr4-dependent inflammatory cell infiltration in airways at a dose of 16 µmol/kg. Additionally, increased urinary EPI-X4 levels, inversely related to glomerular filtration rate (GFR), are observed in chronic kidney disease patients, indicating its potential biomarker role.

• Smiles :

  [H]N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N2CCC[C@H]2C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O.OC(C(F)(F)F)=O

• Molecular Formula :

  C84H144N22O23.XCF3COOH

• Molecular Weight :

  1830.18

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C