EPI-X4 TFA

• Bioactivity:

  EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4) . It effectively prevents calcium mobilization and receptor internalization triggered by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells with CXCR4 expression, at concentrations between 0.8 and 1,000 µM. Moreover, EPI-X4 hampers the CXCL12-driven migration of both Jurkat T cells and human CD34+ hematopoietic stem cells. In an acute allergic airway hypereosinophilia mouse model, EPI-X4 intrinsically decreases Cxcr4-dependent inflammatory cell infiltration in airways at a dose of 16 µmol/kg. Additionally, increased urinary EPI-X4 levels, inversely related to glomerular filtration rate (GFR), are observed in chronic kidney disease patients, indicating its potential biomarker role.

• Smiles:

  [H]N[C@@H] (CC (C) C) C (N[C@@H] (C (C) C) C (N[C@@H] (CCCNC (N) =N) C (N[C@H] (C (N[C@] ([C@@H] (C) O) ([H]) C (N[C@@H] (CCCCN) C (N[C@@H] (CCCCN) C (N[C@@H] (C (C) C) C (N1CCC[C@H]1C (N[C@@H] (CCC (N) =O) C (N[C@@H] (C (C) C) C (N[C@@H] (CO) C (N[C@] ([C@@H] (C) O) ([H]) C (N2CCC[C@H]2C (N[C@] ([C@@H] (C) O) ([H]) C (N[C@@H] (CC (C) C) C (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) CC3=CC=C (O) C=C3) =O) =O) =O.OC (C (F) (F) F) =O

• Molecular Formula:

  C84H144N22O23.XCF3COOH

• Molecular Weight:

  1830.18

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C