MK-8141

• UNSPSC Description:

  MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mk-8141.html

• Smiles:

  O=C(C1=C(C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)C[C@]4([H])CNC[C@@]1([H])N4)N(C5CC5)CC6=CC=CC(C)=C6C

• Molecular Weight:

  620.61

• References & Citations:

  [1]Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors J. Med. Chem., 2009, 52 (12), pp 3689-3702

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  903579-36-2