Products for Research Use Only
RegisterLogin

NEK7 degrader-1

CAT: 0013-GTR19280655-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19280655-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NEK7degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1 nM. It inhibits caspase-1 activity and IL-Ιβ release in macrophages in a dose-dependent manner in response to NLRP3 inflammasome activation. NEK7degrader-1 is useful for researching autoinflammatory and autoimmune diseases (like multiple sclerosis), neurodegenerative disorders (such as Alzheimer's disease), and cardiovascular and pigment diseases (including pericarditis and type 2 diabetes) .
CAS Number
3069891-91-1
Smiles
O=C1NC (=O) C (C2=C (Cl) C=C (C=C2Cl) CNC (=O) C (C3=NC=C (C=N3) C) (C) C) CC1
Molecular Formula
C21H22Cl2N4O3
Molecular Weight
449.33
Notes
For research use only.

Chemical Information

Ghv7HF46BG
CAS Number3069891-91-1
PubChem CID176157253
IUPAC NameN-[[3,5-dichloro-4-(2,6-dioxopiperidin-3-yl)phenyl]methyl]-2-methyl-2-(5-methylpyrimidin-2-yl)propanamide
Molecular FormulaC21H22Cl2N4O3
Molecular Weight449.3
XLogP2.6
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity655
SMILES
CC1=CN=C(N=C1)C(C)(C)C(=O)NCC2=CC(=C(C(=C2)Cl)C3CCC(=O)NC3=O)Cl
InChI
InChI=1S/C21H22Cl2N4O3/c1-11-8-24-19(25-9-11)21(2,3)20(30)26-10-12-6-14(22)17(15(23)7-12)13-4-5-16(28)27-18(13)29/h6-9,13H,4-5,10H2,1-3H3,(H,26,30)(H,27,28,29)
InChIKey
VKROEWYACWPSOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ghv7HF46BG
CAS: 3069891-91-1
CID: 176157253
Formula: C21H22Cl2N4O3
MW: 449.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight449.3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass448.1068960
Monoisotopic Mass448.1068960
Topological Polar Surface Area101 Ų
Heavy Atom Count30
Formal Charge0
Complexity655
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19280759-01NEK7 degrader-2
GTR19241207-01NEK7-IN-1
GTR19241419-01MTH1 degrader-1
GTR19238936-01And1 degrader 1
GTR19237748-01CDK2 degrader 1
GTR19237722-01FOSL1 degrader 1
GTR19236348-01WIZ degrader 1
GTR19234873-01Nrf2 degrader 1
GTR19231336-01HDAC6 degrader-1
GTR19230677-01KRAS degrader-1

Alternative Products

CatalogName
HY-176860-01NEK7 degrader-1
HY-177559NEK7 degrader-2
T203437-01NEK7-IN-1
PPL02175-2aPcDNA3.1 (+) -NEK7
PPL50077-3aPPLK/GFP+Puro-Nek7 shRNA-1
AR50611PU-NNEK7 (1-302, His-tag) Human Protein
K1416902NEK7 sgRNA CRISPR Lentivector (Human) (Target 1)
K6306802Nek7 sgRNA CRISPR Lentivector (Rat) (Target 1)
PVTB50077-3apPLK/GFP+Puro-Nek7 shRNA-1 Plasmid
K4470902Nek7 sgRNA CRISPR Lentivector (Mouse) (Target 1)

Popular Products