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PROTAC BCR-ABL Degrader-2

CAT: 0013-GTR19277127-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277127-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACBCR-ABLDegrader-2 is a selective Bcr-Abl T315I PROTAC degrader with a DC50 of 108.7 nM in Ba/F3 Bcr-AblT315I cells. It demonstrates potent degradation activity with rates of 69.89% at 100 nM and 94.23% at 300 nM concentrations. In vivo, PROTACBCR-ABLDegrader-2 exhibits good plasma exposure, induces significant tumor regression, triggers apoptosis (apoptosis), and maintains a favorable safety profile. This compound is suitable for chronic myelogenous leukemia research.
CAS Number
2703834-25-5
Smiles
O=C (NC1=CC=C (C (=C1) C (F) (F) F) CN2CCN (CC2) CCCCCCC (=O) NC3=CC=CC=4C (=O) N (C (=O) C34) C5C (=O) NC (=O) CC5) C6=CC=C (C (C#CC=7C=NC=8NN=CC8C7) =C6) C
Molecular Formula
C48H46F3N9O6
Molecular Weight
901.95
Storage Conditions
-20°C
Notes
For research use only.

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