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DFCI-002-06

CAT: 0013-GTR19277111-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277111-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DFCI-002-06 is an orally active dual-targeted HCK/BTK PROTAC degrader, demonstrating DC50 values of 1.3 nM for HCK and 4.5 nM for BTK. It retains superior antitumor activity compared to dual-targeted HCK/BTK inhibitors and induces apoptosis in cancer cells. DFCI-002-06 is applicable in studies of MYD88-mutant B-cell malignancies.
CAS Number
3092208-36-8
Smiles
NC1=C2C (=NN (C2=NC=N1) [C@H]3CC[C@@H] (CC3) N4CCN (CC5CN (C5) C=6C=C7C (=CC6) C (=O) N (C7=O) C8C (=O) NC (=O) CC8) CC4) C9=CC=C (OC%10=CC=CC=C%10) C=C9
Molecular Formula
C44H46N10O5
Molecular Weight
794.92
Storage Conditions
-20°C
Notes
For research use only.

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