PVD-06

• Description:

  PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B) . PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma[1]. (Pink: PTPN2 ligand (HY-168691), Black: linker (HY-B0236), Blue: VHL ligand (HY-112078) ) .

• UNSPSC:

  12352005

• Target:

  IFNAR; Phosphatase; PROTACs; STAT

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pvd-06.html

• Purity:

  98.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC(C(F)(F)F)=O.O=C(CN1N=CC(C2=CC=C3C=C(C(N4CC(NS4(=O)=O)=O)=C(C3=C2)F)O)=C1)NCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O

• Molecular Formula:

  C48H55F4N9O11S2

• Molecular Weight:

  1074.13

• References & Citations:

  [1]Hu L et al. Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader. J Med Chem. 2023 Nov 23;66 (22) :15269-15287.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3032975-48-4]